Activate Your RAS
نویسندگان
چکیده
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EXTRACT Although there are new ways to portray the brain, colored and computerized encephalography but Coma is still unknown and such as death remain beyond comprehension and knowing. Is not it ? Perhaps because of this, despite knowing that some part of the brain is not yet fully understood all its parts. But knowing the components that working to each other is key for discovering a lot of...
متن کاملRas-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo. We found that Ras-GRF/Cdc25Mm activates Ha...
متن کاملR-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
BACKGROUND The small GTPase R-Ras displays a less potent transforming activity than the closely related Ras oncogene products. Although R-Ras has been reported to interact with c-Raf1 and Ral-GDS in vitro, the pathways by which it exerts its effects on cellular proliferation are not known. RESULTS Both Ras and R-Ras interact with phosphoinositide (PI) 3-kinase in vitro, and induce elevation o...
متن کاملRas-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway.
Rat sarcoma (Ras) GTPases regulate cell proliferation and survival through effector pathways including Raf-MAPK, and are the most frequently mutated genes in human cancer. Although it is well established that Ras activity requires binding to both GTP and the membrane, details of how Ras operates on the cell membrane to activate its effectors remain elusive. Efforts to target mutant Ras in human...
متن کاملRas isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase.
Ha-, N-, and Ki-Ras are ubiquitously expressed in mammalian cells and can all interact with the same set of effector proteins. We show here, however, that in vivo there are marked quantitative differences in the ability of Ki- and Ha-Ras to activate Raf-1 and phosphoinositide 3-kinase. Thus, Ki-Ras both recruits Raf-1 to the plasma membrane more efficiently than Ha-Ras and is a more potent acti...
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تاریخ انتشار 2014